Heterogeneity of leukotriene receptions in guinea-pig trachea
RD Krell, BS Tsai, A Berdoulay, M Barone, RE Giles - Prostaglandins, 1983 - Elsevier
The selective leukotriene (LT) antagonist FPL 55712 antagonized the contractile activity of
synthetic LTD 4 and E 4 on guinea-pig trachea. Schild analysis of the antagonism provided
evidence for two distinct receptors for LTD 4: one with significantly higher affinity for FPL
55712 than the other. LTE 4 appears to interact preferentially with the high affinity receptor.
synthetic LTD 4 and E 4 on guinea-pig trachea. Schild analysis of the antagonism provided
evidence for two distinct receptors for LTD 4: one with significantly higher affinity for FPL
55712 than the other. LTE 4 appears to interact preferentially with the high affinity receptor.