[HTML][HTML] The effects of anti-inflammatory drug treatment in gastric cancer prevention: an update of a meta-analysis

P Kong, R Wu, X Liu, J Liu, S Chen, M Ye… - Journal of …, 2016 - ncbi.nlm.nih.gov
P Kong, R Wu, X Liu, J Liu, S Chen, M Ye, C Yang, Z Song, W He, C Yin, Q Yang, C Jiang…
Journal of Cancer, 2016ncbi.nlm.nih.gov
Gastric cancer has high incidence and fatality rates, making chemoprevention agents
necessary. There is an ongoing debate about aspirin/nonsteroidal anti-inflammatory drugs
(NSAIDs) use can significant reduce the risk of GC. We conducted a meta-analysis of
existing studies evaluating the association of anti-inflammatory drug and GC. We performed
a systematic literature search of PubMed, Web of Science, Embase, OVID, Cochrane Library
and Clincialtrials. gov up to August 31, 2015. Either a fixed-effects or a random-effects model …
Abstract
Gastric cancer has high incidence and fatality rates, making chemoprevention agents necessary. There is an ongoing debate about aspirin/nonsteroidal anti-inflammatory drugs (NSAIDs) use can significant reduce the risk of GC. We conducted a meta-analysis of existing studies evaluating the association of anti-inflammatory drug and GC. We performed a systematic literature search of PubMed, Web of Science, Embase, OVID, Cochrane Library and Clincialtrials. gov up to August 31, 2015. Either a fixed-effects or a random-effects model using was based on the result of homogeneity analysis. Subgroup, sensitivity, meta-regression, and publication bias analyses were evaluated. Forty-seven studies were finally included in this meta-analysis. The overall GC risk reduction benefit associated with anti-inflammatory drug use represented an RR of 0.78 (95% CI 0.71 to 0.85) and an adjusted RR of 0.74 (95% CI 0.71 to 0.77). Besides, the prevention benefit of aspirin/NSAIDs ingestion appeared to be confined to those patients with regiment of short or middle-term (≤ 5 years), high-frequency (> 30 times per month) and low dose (< 200 mg per day). Further, our data also suggest that COX-2 inhibitors use is a more effective approach in GC prevention (RR, 0.45; 95% CI, 0.29-0.70). In this meta-analysis, our finding support short or middle-term (≤ 5 years), high-frequency (> 30 times per month) and low dose (< 200 mg per day) aspirin/NSAIDs intake is a well method for GC prevention and also confirm the inverse association between aspirin/NSAIDs use and GC risk. Additionally, selective COX-2 inhibitors use probably a more effective approach to reduce GC risk.
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