[HTML][HTML] Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration
FIP200 (FAK family-interacting protein of 200 kDa) is a conserved protein recently identified
as a potential mammalian counterpart of yeast autophagy protein Atg17. However, it
remains unknown whether mammalian FIP200 regulates autophagy in vivo. Here we show
that neural-specific deletion of FIP200 resulted in cerebellar degeneration accompanied by
progressive neuronal loss, spongiosis, and neurite degeneration in the cerebellum.
Furthermore, deletion of FIP200 led to increased apoptosis in cerebellum as well as …
as a potential mammalian counterpart of yeast autophagy protein Atg17. However, it
remains unknown whether mammalian FIP200 regulates autophagy in vivo. Here we show
that neural-specific deletion of FIP200 resulted in cerebellar degeneration accompanied by
progressive neuronal loss, spongiosis, and neurite degeneration in the cerebellum.
Furthermore, deletion of FIP200 led to increased apoptosis in cerebellum as well as …