Bone morphogenetic protein-7 inhibits silica-induced pulmonary fibrosis in rats
G Yang, Z Zhu, Y Wang, A Gao, P Niu, L Tian - Toxicology letters, 2013 - Elsevier
Abstract Bone morphogenetic protein-7 (BMP-7) has been shown to inhibit liver and renal
fibrosis in in vivo and vitro studies. There is no study to investigate BMP-7's role in the
development of pulmonary fibrosis induced by silica. In the current study, we used the rat
model to explore the potential antifibrotic role of BMP-7 and its underlying mechanism in
silica-induced pulmonary fibrosis. Sixty Wistar rats were randomly assigned into three
groups. Control group received saline, silica group received silica and BMP-7 treated group …
fibrosis in in vivo and vitro studies. There is no study to investigate BMP-7's role in the
development of pulmonary fibrosis induced by silica. In the current study, we used the rat
model to explore the potential antifibrotic role of BMP-7 and its underlying mechanism in
silica-induced pulmonary fibrosis. Sixty Wistar rats were randomly assigned into three
groups. Control group received saline, silica group received silica and BMP-7 treated group …