[HTML][HTML] Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors
M Sanchez-Alavez, O Osborn, IV Tabarean… - Journal of Biological …, 2011 - ASBMB
The objective is to investigate the role of insulin-like growth factor 1 (IGF-1) in the regulation
of core body temperature. Sequencing cDNA libraries from individual warm-sensitive
neurons from the preoptic area (POA) of the hypothalamus, a region involved in the central
control of thermoregulation, identified neurons that express both IGF-1 receptor (IGF-1R)
and insulin receptor transcripts. The effects of administration of IGF-1 into the POA was
measured by radiotelemetry monitoring of core temperature, brown adipose tissue (BAT) …
of core body temperature. Sequencing cDNA libraries from individual warm-sensitive
neurons from the preoptic area (POA) of the hypothalamus, a region involved in the central
control of thermoregulation, identified neurons that express both IGF-1 receptor (IGF-1R)
and insulin receptor transcripts. The effects of administration of IGF-1 into the POA was
measured by radiotelemetry monitoring of core temperature, brown adipose tissue (BAT) …