Helicobacter pylori affects the cellular deubiquitinase USP7 and ubiquitin-regulated components TRAF6 and the tumour suppressor p53
N Coombs, R Sompallae, P Olbermann… - International Journal of …, 2011 - Elsevier
Helicobacter pylori is a recognized cancerogenic bacterial agent in humans, associated with
gastritis, peptic ulcer, and gastric cancer. Immunoevasive and immunomodulatory
mechanisms underlie the chronic persistence of the bacterium and the active
proinflammatory effect of life-long H. pylori infection. In contrast to tumorigenic viruses, which
frequently possess factors to influence the host ubiquitin-proteasome system (UPS), nothing
is yet known about potential effects of H. pylori in this respect. The majority of H. pylori …
gastritis, peptic ulcer, and gastric cancer. Immunoevasive and immunomodulatory
mechanisms underlie the chronic persistence of the bacterium and the active
proinflammatory effect of life-long H. pylori infection. In contrast to tumorigenic viruses, which
frequently possess factors to influence the host ubiquitin-proteasome system (UPS), nothing
is yet known about potential effects of H. pylori in this respect. The majority of H. pylori …