Distinguishing primary and secondary translocations in multiple myeloma
A Gabrea, PL Bergsagel, WM Kuehl - DNA repair, 2006 - Elsevier
Multiple myeloma (MM) is a malignant post-germinal center tumor of somatically-mutated,
isotype-switched plasma cells that accumulate in the bone marrow. It often is preceded by a
stable pre-malignant tumor called monoclonal gammopathy of undetermined significance
(MGUS), which can sporadically progress to MM. Five recurrent primary translocations
involving the immunoglobulin heavy chain (IgH) locus on chromosome 14q32 have been
identified in MGUS and MM tumors. The five partner loci include 11q13, 6p21, 4p16, 16q23 …
isotype-switched plasma cells that accumulate in the bone marrow. It often is preceded by a
stable pre-malignant tumor called monoclonal gammopathy of undetermined significance
(MGUS), which can sporadically progress to MM. Five recurrent primary translocations
involving the immunoglobulin heavy chain (IgH) locus on chromosome 14q32 have been
identified in MGUS and MM tumors. The five partner loci include 11q13, 6p21, 4p16, 16q23 …