Multiple myeloma: evolving genetic events and host interactions

WM Kuehl, PL Bergsagel - Nature Reviews Cancer, 2002 - nature.com
WM Kuehl, PL Bergsagel
Nature Reviews Cancer, 2002nature.com
Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which
chromosome translocations frequently place oncogenes under the control of
immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often
has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What
causes full-blown myeloma? And can our molecular understanding of this common
haematological malignancy be used to develop effective preventive and treatment …
Abstract
Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?
nature.com