[HTML][HTML] Change in the fatty acid pattern of erythrocyte membrane phospholipids after oral supplementation of specific fatty acids in patients with gastrointestinal …
R Siener, B Alteheld, B Terjung, B Junghans… - European journal of …, 2010 - nature.com
European journal of clinical nutrition, 2010•nature.com
Results: Supplementation with FA-ADEK increased ALA, DHA and eicosapentaenoic acid
(EPA) concentrations of erythrocyte membrane phospholipids by 0.040, 1.419 and 0.159%,
respectively, compared with ADEK supplementation (− 0.007, 0.151 and 0.002%,
respectively) after 12 weeks (all P⩽ 0.001). Serum GGT activity decreased in patients
receiving FA-ADEK compared with those receiving ADEK with a significant difference after 8
weeks. Conclusions: The significant change in erythrocyte membrane fatty acid pattern …
(EPA) concentrations of erythrocyte membrane phospholipids by 0.040, 1.419 and 0.159%,
respectively, compared with ADEK supplementation (− 0.007, 0.151 and 0.002%,
respectively) after 12 weeks (all P⩽ 0.001). Serum GGT activity decreased in patients
receiving FA-ADEK compared with those receiving ADEK with a significant difference after 8
weeks. Conclusions: The significant change in erythrocyte membrane fatty acid pattern …
Results:
Supplementation with FA-ADEK increased ALA, DHA and eicosapentaenoic acid (EPA) concentrations of erythrocyte membrane phospholipids by 0.040, 1.419 and 0.159%, respectively, compared with ADEK supplementation (− 0.007, 0.151 and 0.002%, respectively) after 12 weeks (all P⩽ 0.001). Serum GGT activity decreased in patients receiving FA-ADEK compared with those receiving ADEK with a significant difference after 8 weeks.
Conclusions:
The significant change in erythrocyte membrane fatty acid pattern demonstrates the incorporation of orally administered n-3 PUFA in patients with maldigestion and malabsorption. The increase in ALA and DHA, as well as the conversion of ALA to EPA is attributed to the supplementation of sufficient amounts of ALA and DHA, respectively. Serum GGT activity decreased in response to decreased oxidative stress.
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