[HTML][HTML] Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase
BH Maskrey, A Bermudez-Fajardo, AH Morgan… - Journal of Biological …, 2007 - ASBMB
12/15-Lipoxygenase (LOX) mediates immune-regulatory activities not accounted for by its
known free acid eicosanoids, suggesting that additional lipids may be generated by
activated cells. To characterize novel LOX-derived lipids, a lipidomic approach was utilized.
Ionophore-activated interleukin-4-treated human peripheral monocytes generated up to 10-
fold more esterified 15-hydroxyeicosatetraenoic acid (15-HETE) than free in a
phosphatidylinositol 3-kinase-and protein kinase C-sensitive manner. Precursor scanning …
known free acid eicosanoids, suggesting that additional lipids may be generated by
activated cells. To characterize novel LOX-derived lipids, a lipidomic approach was utilized.
Ionophore-activated interleukin-4-treated human peripheral monocytes generated up to 10-
fold more esterified 15-hydroxyeicosatetraenoic acid (15-HETE) than free in a
phosphatidylinositol 3-kinase-and protein kinase C-sensitive manner. Precursor scanning …