[HTML][HTML] Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth …
A Loidl, E Sevcsik, G Riesenhuber, HP Deigner… - Journal of Biological …, 2003 - ASBMB
Oxidized phospholipids, including 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine
(PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), typically
present in minimally modified low density lipoprotein, have been found in atherosclerotic
lesions. These compounds are gaining increasing importance as inducers of different
cellular responses (inflammation, proliferation, or cell death). It was the aim of this study to
understand their impact on intracellular signal transduction pathways that are responsible …
(PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), typically
present in minimally modified low density lipoprotein, have been found in atherosclerotic
lesions. These compounds are gaining increasing importance as inducers of different
cellular responses (inflammation, proliferation, or cell death). It was the aim of this study to
understand their impact on intracellular signal transduction pathways that are responsible …