[HTML][HTML] Cytosolic phospholipase A2: physiological function and role in disease
CC Leslie - Journal of lipid research, 2015 - ASBMB
The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and-
ζ. They contain a Ser-Asp catalytic dyad and all except cPLA 2 γ have a C2 domain, but
differences in their catalytic activities and subcellular localization suggest unique regulation
and function. With the exception of cPLA 2 α, the focus of this review, little is known about the
in vivo function of group IV enzymes. cPLA 2 α catalyzes the hydrolysis of phospholipids to …
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and-
ζ. They contain a Ser-Asp catalytic dyad and all except cPLA 2 γ have a C2 domain, but
differences in their catalytic activities and subcellular localization suggest unique regulation
and function. With the exception of cPLA 2 α, the focus of this review, little is known about the
in vivo function of group IV enzymes. cPLA 2 α catalyzes the hydrolysis of phospholipids to …