The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease
LJ Jackson, JA Pheneger, TJ Pheneger, G Davis… - Cellular …, 2012 - Elsevier
PIM kinases are a family of three serine/threonine kinases expressed following T cell
activation. Using potent selective small molecule antagonists of PIM-1/3 kinases, we
demonstrate a potential role for these enzymes in naïve and effector CD4+ T cell activation.
PIM-1/3 inhibition prevented CD4+ T cell proliferation by inducing a G0/G1 cell cycle arrest
without affecting cellular survival. In the absence of PIM-1/3 kinase activity, naïve CD4+ T
cells failed to fully differentiate into effector cells both in vitro and in vivo. Therapeutic dosing …
activation. Using potent selective small molecule antagonists of PIM-1/3 kinases, we
demonstrate a potential role for these enzymes in naïve and effector CD4+ T cell activation.
PIM-1/3 inhibition prevented CD4+ T cell proliferation by inducing a G0/G1 cell cycle arrest
without affecting cellular survival. In the absence of PIM-1/3 kinase activity, naïve CD4+ T
cells failed to fully differentiate into effector cells both in vitro and in vivo. Therapeutic dosing …