Regulation of the extent of immune responses is a requirement to maintain self-tolerance
and limit inflammatory processes. CD4+ CD25+ Foxp3+ regulatory T (Treg) cells play a role
in regulation. The Foxp3 transcription factor is considered a dominant regulator for Treg cell
development and function. Foxp3 function itself is directly regulated by multiple
posttranslational modifications that occur in response to various external stimuli. The Foxp3
protein is a component of several dynamic macromolecular regulatory complexes. The …