[HTML][HTML] Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells
Pyruvate kinase M2 (PKM2) is a key player in the Warburg effect of cancer cells. However,
the mechanisms of regulating PKM2 are not fully elucidated. Here, we identified the protein-
serine/threonine kinase PIM2, a known oncogene, as a novel binding partner of PKM2. The
interaction between PIM2 and PKM2 was confirmed by multiple biochemical approaches in
vitro and in cultured cells. Importantly, we found that PIM2 could directly phosphorylate
PKM2 on the Thr-454 residue, resulting in an increase of PKM2 protein levels. Compared …
the mechanisms of regulating PKM2 are not fully elucidated. Here, we identified the protein-
serine/threonine kinase PIM2, a known oncogene, as a novel binding partner of PKM2. The
interaction between PIM2 and PKM2 was confirmed by multiple biochemical approaches in
vitro and in cultured cells. Importantly, we found that PIM2 could directly phosphorylate
PKM2 on the Thr-454 residue, resulting in an increase of PKM2 protein levels. Compared …