[HTML][HTML] The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells
I Sakai, AS Kraft - Journal of Biological Chemistry, 1997 - ASBMB
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5
stimulate DNA synthesis and proliferation and inhibit apoptosis in hematopoietic cells.
Multiple signal pathways are activated by binding of these ligands to their receptors, which
share a common β subunit. Janus protein kinase 2 (Jak2) binds to the membrane proximal
domain of the β chain and is phosphorylated on receptor ligation. To explore the role of Jak2
in the regulation of specific signal transduction pathways, we constructed fusion proteins …
stimulate DNA synthesis and proliferation and inhibit apoptosis in hematopoietic cells.
Multiple signal pathways are activated by binding of these ligands to their receptors, which
share a common β subunit. Janus protein kinase 2 (Jak2) binds to the membrane proximal
domain of the β chain and is phosphorylated on receptor ligation. To explore the role of Jak2
in the regulation of specific signal transduction pathways, we constructed fusion proteins …