Background Resolution is the final stage of the inflammatory response, when restoration of
tissue occurs. Failure may lead to chronic inflammation, which is known as part of the
pathology in the brain of individuals with Alzheimer's disease (AD). Methods Specialized pro-
resolving mediators (SPMs), receptors, biosynthetic enzyme, and downstream effectors
involved in resolution were analyzed in postmortem hippocampal tissue from AD patients
and non-AD subjects. SPMs were analyzed in cerebrospinal fluid (CSF). Results SPMs and …