Novel tight-binding inhibitors of leukotriene A4 hydrolase
W Yuan, CH Wong, JZ Haeggstroem… - Journal of the …, 1992 - ACS Publications
W Yuan, CH Wong, JZ Haeggstroem, A Wetterholm, B Samuelsson
Journal of the American Chemical Society, 1992•ACS PublicationsLeukotriene (LT) A4 hydrolase (EC 3.3. 2.6) 1 is a zinc-con-taining2 monomeric enzyme
(MW= 70 kDa) which catalyzes the formation of LTB4 (5 (5), 12 (J?)-dihydroxy-6, 14-m-8, 10-
trans-eicosatetraenoic acid) from its natural substrate LTA4 ((55)-5, 6-oxido-7, 9-ira/ul 1, 14-
cfs-eicosatetraenoic acid), 3· 4 one of the
(MW= 70 kDa) which catalyzes the formation of LTB4 (5 (5), 12 (J?)-dihydroxy-6, 14-m-8, 10-
trans-eicosatetraenoic acid) from its natural substrate LTA4 ((55)-5, 6-oxido-7, 9-ira/ul 1, 14-
cfs-eicosatetraenoic acid), 3· 4 one of the
Leukotriene (LT) A4 hydrolase (EC 3.3. 2.6) 1 is a zinc-con-taining2 monomeric enzyme (MW= 70 kDa) which catalyzes the formation of LTB4 (5 (5), 12 (J?)-dihydroxy-6, 14-m-8, 10-trans-eicosatetraenoic acid) from its natural substrate LTA4 ((55)-5, 6-oxido-7, 9-ira/ul 1, 14-cfs-eicosatetraenoic acid), 3· 4 one of the
ACS Publications