Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans

RG Cutler, KW Thompson, S Camandola… - Mechanisms of ageing …, 2014 - Elsevier
Sphingolipids are a highly conserved lipid component of cell membranes involved in the
formation of lipid raft domains that house many of the receptors and cell-to-cell signaling
factors involved in regulating cell division, maturation, and terminal differentiation. By
measuring and manipulating sphingolipid metabolism using pharmacological and genetic
tools in Caenorhabditis elegans, we provide evidence that the synthesis and remodeling of
specific ceramides (eg, dC18: 1–C24: 1), gangliosides (eg, GM1–C24: 1), and …