[HTML][HTML] Sphingolipid distribution changes with age in the human lens [S]
JM Deeley, JA Hankin, MG Friedrich, RC Murphy… - Journal of lipid …, 2010 - ASBMB
The formation of an internal barrier to the diffusion of small molecules in the lens during
middle age is hypothesized to be a key event in the development of age-related nuclear
(ARN) cataract. Changes in membrane lipids with age may be responsible. In this study, we
investigated the effect of age on the distribution of sphingomyelins, the most abundant lens
phospholipids. Human lens sections were initially analyzed by MALDI mass spectrometry
imaging. A distinct annular distribution of the dihydrosphingomyelin, DHSM (d18: 0/16: 0), in …
middle age is hypothesized to be a key event in the development of age-related nuclear
(ARN) cataract. Changes in membrane lipids with age may be responsible. In this study, we
investigated the effect of age on the distribution of sphingomyelins, the most abundant lens
phospholipids. Human lens sections were initially analyzed by MALDI mass spectrometry
imaging. A distinct annular distribution of the dihydrosphingomyelin, DHSM (d18: 0/16: 0), in …