[HTML][HTML] Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-κB activity
D Wu, M Marko, K Claycombe, KE Paulson… - Journal of Biological …, 2003 - ASBMB
We have shown that the age-associated increase in lipopolysaccharide (LPS)-stimulated
macrophages (Mφ) prostaglandin E 2 (PGE 2) production is because of ceramide-induced
up-regulation of cyclooxygenase (COX)-2 transcription that leads to increased COX-2
expression and enzyme activity. To determine the mechanism of the age-related and
ceramide-dependent increase in COX-2 transcription, we investigated the role of various
transcription factors involved in COX-2 gene expression. The results showed that LPS …
macrophages (Mφ) prostaglandin E 2 (PGE 2) production is because of ceramide-induced
up-regulation of cyclooxygenase (COX)-2 transcription that leads to increased COX-2
expression and enzyme activity. To determine the mechanism of the age-related and
ceramide-dependent increase in COX-2 transcription, we investigated the role of various
transcription factors involved in COX-2 gene expression. The results showed that LPS …