Infections in IFNGR-1-deficient children

E JOUANGUY, F ALTARE… - Journal of interferon & …, 1997 - liebertpub.com
E JOUANGUY, F ALTARE, S LAMHAMEDI-CHERRADI, JL CASANOVA
Journal of interferon & cytokine research, 1997liebertpub.com
Human interferon-γ receptor 1 (IFNGR-1) deficiency is a newly identified autosomal
recessive inherited immune disorder. Children with IFNGR-1 deficiency exhibit a severe,
profound and selective susceptibility to weakly virulent mycobacteria, such as bacillus
Calmette-Guérin (BCG) vaccine or environmental nontubcrculous mycobacteria (NTM). This
review compares the infections found in IFNGR-1-deficient children to those in IFN-γ-
deficient or IFNGR-1-deficient mice.
Human interferon-γ receptor 1 (IFNGR-1) deficiency is a newly identified autosomal recessive inherited immune disorder. Children with IFNGR-1 deficiency exhibit a severe, profound and selective susceptibility to weakly virulent mycobacteria, such as bacillus Calmette-Guérin (BCG) vaccine or environmental nontubcrculous mycobacteria (NTM). This review compares the infections found in IFNGR-1-deficient children to those in IFN-γ-deficient or IFNGR-1-deficient mice.
Mary Ann Liebert