MicroRNA-138 regulates the balance of Th1/Th2 via targeting RUNX3 in psoriasis
D Fu, W Yu, M Li, H Wang, D Liu, X Song, Z Li, Z Tian - Immunology Letters, 2015 - Elsevier
Psoriasis is a common chronic inflammatory and T cell-meditated autoimmune skin disease.
A recent study found that Runt-related transcription factor 3 (RUNX3) is a susceptibility gene
for psoriasis; however, its biological role in the disease has not been studied. RUNX3 was
predicted to be the target gene of microRNA-138 (miR-138). The current research was
designed to delineate the mechanism of miR-138 in regulating psoriasis via targeting
RUNX3. In this study, we found that the expression of RUNX3 is increased significantly while …
A recent study found that Runt-related transcription factor 3 (RUNX3) is a susceptibility gene
for psoriasis; however, its biological role in the disease has not been studied. RUNX3 was
predicted to be the target gene of microRNA-138 (miR-138). The current research was
designed to delineate the mechanism of miR-138 in regulating psoriasis via targeting
RUNX3. In this study, we found that the expression of RUNX3 is increased significantly while …