[HTML][HTML] Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jκ or nuclear localization sequences retain the ability to associate with RBP-Jκ …
JC Aster, ES Robertson, RP Hasserjian… - Journal of Biological …, 1997 - ASBMB
Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant
forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL)
efficiently induce T-ALL when expressed in the bone marrow of mice. Unlike full-sized
NOTCH1, two such truncated forms of the protein either lacking a major portion of the
extracellular domain (ΔE) or consisting only of the intracellular domain (ICN) were found to
activate transcription in cultured cells, presumably through RBP-Jκ response elements …
forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL)
efficiently induce T-ALL when expressed in the bone marrow of mice. Unlike full-sized
NOTCH1, two such truncated forms of the protein either lacking a major portion of the
extracellular domain (ΔE) or consisting only of the intracellular domain (ICN) were found to
activate transcription in cultured cells, presumably through RBP-Jκ response elements …