[HTML][HTML] TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants–past, present and future
LM Sedger, MF McDermott - Cytokine & growth factor reviews, 2014 - Elsevier
Abstract Tumor Necrosis Factor (TNF), initially known for its tumor cytotoxicity, is a potent
mediator of inflammation, as well as many normal physiological functions in homeostasis
and health, and anti-microbial immunity. It also appears to have a central role in
neurobiology, although this area of TNF biology is only recently emerging. Here, we review
the basic biology of TNF and its normal effector functions, and discuss the advantages and
disadvantages of therapeutic neutralization of TNF–now a commonplace practice in the …
mediator of inflammation, as well as many normal physiological functions in homeostasis
and health, and anti-microbial immunity. It also appears to have a central role in
neurobiology, although this area of TNF biology is only recently emerging. Here, we review
the basic biology of TNF and its normal effector functions, and discuss the advantages and
disadvantages of therapeutic neutralization of TNF–now a commonplace practice in the …