Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent β-catenin activation
S Utley, D James, N Mavila, MV Nguyen… - Journal of …, 2014 - Elsevier
Background & Aims Fibroblast Growth Factors (FGFs) promote the proliferation and survival
of hepatic progenitor cells (HPCs) via AKT-dependent β-catenin activation. Moreover, the
emergence of hepatocytes expressing the HPC marker A6 during 3, 5-diethoxycarbonyl-1, 4-
dihydrocollidine (DDC)-induced liver injury is mediated partly by FGF and β-catenin
signaling. Herein, we investigate the role of FGF signaling and AKT-mediated β-catenin
activation in acute DDC liver injury. Methods Transgenic mice were fed DDC chow for 14 …
of hepatic progenitor cells (HPCs) via AKT-dependent β-catenin activation. Moreover, the
emergence of hepatocytes expressing the HPC marker A6 during 3, 5-diethoxycarbonyl-1, 4-
dihydrocollidine (DDC)-induced liver injury is mediated partly by FGF and β-catenin
signaling. Herein, we investigate the role of FGF signaling and AKT-mediated β-catenin
activation in acute DDC liver injury. Methods Transgenic mice were fed DDC chow for 14 …