[HTML][HTML] SHIP1 and Lyn kinase negatively regulate integrin αIIbβ3 signaling in platelets
Integrin α IIb β 3 plays a critical role in platelet function, promoting a broad range of
functional responses including platelet adhesion, spreading, aggregation, clot retraction,
and platelet procoagulant function. Signaling events operating downstream of this receptor
(outside-in signaling) are important for these responses; however the mechanisms
negatively regulating integrin α IIb β 3 signaling remain ill-defined. We demonstrate here a
major role for the Src homology 2 domain-containing inositol 5-phosphatase (SHIP1) and …
functional responses including platelet adhesion, spreading, aggregation, clot retraction,
and platelet procoagulant function. Signaling events operating downstream of this receptor
(outside-in signaling) are important for these responses; however the mechanisms
negatively regulating integrin α IIb β 3 signaling remain ill-defined. We demonstrate here a
major role for the Src homology 2 domain-containing inositol 5-phosphatase (SHIP1) and …