Alpha-synuclein aggregates are excluded from calbindin-D28k-positive neurons in dementia with Lewy bodies and a unilateral rotenone mouse model
AN Rcom-H'cheo-Gauthier, A Davis… - Molecular and Cellular …, 2016 - Elsevier
Abstract α-Synuclein (α-syn) aggregates (Lewy bodies) in Dementia with Lewy Bodies (DLB)
may be associated with disturbed calcium homeostasis and oxidative stress. We
investigated the interplay between α-syn aggregation, expression of the calbindin-D28k
(CB) neuronal calcium-buffering protein and oxidative stress, combining
immunofluorescence double labelling and Western analysis, and examining DLB and
normal human cases and a unilateral oxidative stress lesion model of α-syn disease …
may be associated with disturbed calcium homeostasis and oxidative stress. We
investigated the interplay between α-syn aggregation, expression of the calbindin-D28k
(CB) neuronal calcium-buffering protein and oxidative stress, combining
immunofluorescence double labelling and Western analysis, and examining DLB and
normal human cases and a unilateral oxidative stress lesion model of α-syn disease …