Glucocerebrosidase mutations: tipping point toward Parkinson disease and dementia?
THE ACCUMULATION AND AGGREGATION OF mutant proteins that are commonly ob-
served in different neurodegenerative dis-orders is suggestive of a shared pathogenic
mechanism. Recent data indicate that the elimination of the accumulation of mutant proteins
can halt the symptomatic progression of neurodegeneration and can also lead to the
regression of disease. This has been best demonstrated through conditional mouse models,
in which the elimination of the expression of disease-linked proteins such as-synuclein …
served in different neurodegenerative dis-orders is suggestive of a shared pathogenic
mechanism. Recent data indicate that the elimination of the accumulation of mutant proteins
can halt the symptomatic progression of neurodegeneration and can also lead to the
regression of disease. This has been best demonstrated through conditional mouse models,
in which the elimination of the expression of disease-linked proteins such as-synuclein …