[HTML][HTML] Identification of transcriptional networks during liver regeneration
P White, JE Brestelli, KH Kaestner… - Journal of Biological …, 2005 - ASBMB
The molecular analysis of mammalian cellular proliferation in vivo is limited in most organ
systems by the low turnover and/or the asynchronous nature of cell cycle progression. A
notable exception is the partial hepatectomy model, in which quiescent hepatocytes reenter
the cell cycle and progress in a synchronous fashion. Here we have exploited this model to
identify regulatory networks operative in the mammalian cell cycle. We performed microarray-
based expression profiling on livers 0-40 h post-hepatectomy corresponding to G 0, G 1, and …
systems by the low turnover and/or the asynchronous nature of cell cycle progression. A
notable exception is the partial hepatectomy model, in which quiescent hepatocytes reenter
the cell cycle and progress in a synchronous fashion. Here we have exploited this model to
identify regulatory networks operative in the mammalian cell cycle. We performed microarray-
based expression profiling on livers 0-40 h post-hepatectomy corresponding to G 0, G 1, and …