PBK/TOPK in the differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma and its involvement in prognosis of human cholangiocarcinoma
F He, Q Yan, L Fan, Y Liu, J Cui, J Wang, L Wang… - Human pathology, 2010 - Elsevier
The increased expression of PDZ binding kinase/lymphokine-activated killer T-cell–
originated protein kinase (PBK/TOPK) is associated with some human malignant tumors. In
this study, we analyzed PBK/TOPK expression in hepatic primary tumor and explored its role
in cholangiocarcinoma biology. Seventy-four cholangiocarcinomas, 33 hepatocellular
carcinomas, and 10 normal liver tissues were prepared from paraffin-embedded specimens.
PBK/TOPK protein was assessed by immunohistochemical staining, and the survival time …
originated protein kinase (PBK/TOPK) is associated with some human malignant tumors. In
this study, we analyzed PBK/TOPK expression in hepatic primary tumor and explored its role
in cholangiocarcinoma biology. Seventy-four cholangiocarcinomas, 33 hepatocellular
carcinomas, and 10 normal liver tissues were prepared from paraffin-embedded specimens.
PBK/TOPK protein was assessed by immunohistochemical staining, and the survival time …