Decitabine.
SD Gore, C Jones, P Kirkpatrick - Nature reviews Drug …, 2006 - search.ebscohost.com
SD Gore, C Jones, P Kirkpatrick
Nature reviews Drug discovery, 2006•search.ebscohost.comDecitabine Page 1 Azacitidine Decitabine 4-amino-1-(2-deoxy-βD-erythro-pentofuranosyl)-
1,3,5-triazin-2(1H)-one C8H12N4O4; Mr = 228.21 N N NH2 O N O OH OH HO N N NH2 O N O
OH HO a b FRESH FROM THE PIPELINE Decitabine Steven D. Gore, Carole Jones and Peter
Kirkpatrick Decitabine Figure 1 | DNA methyltransferase inhibitors. a | Azacitidine. b |
Decitabine. Decitabine seems to be only incorporated into DNA, whereas azacitidine is also
incorporated into RNA3. Decitabine (Dacogen; MGI Pharma), a nucleoside analogue that …
1,3,5-triazin-2(1H)-one C8H12N4O4; Mr = 228.21 N N NH2 O N O OH OH HO N N NH2 O N O
OH HO a b FRESH FROM THE PIPELINE Decitabine Steven D. Gore, Carole Jones and Peter
Kirkpatrick Decitabine Figure 1 | DNA methyltransferase inhibitors. a | Azacitidine. b |
Decitabine. Decitabine seems to be only incorporated into DNA, whereas azacitidine is also
incorporated into RNA3. Decitabine (Dacogen; MGI Pharma), a nucleoside analogue that …
Abstract Decitabine (Dacogen; MGI Pharma), a nucleoside analogue that inhibits DNA methylation, was approved by the US FDA for the treatment of myelodysplastic syndromes in May 2006.
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