[HTML][HTML] Differential dependence of hypoxia-inducible factors 1α and 2α on mTORC1 and mTORC2
A Toschi, E Lee, N Gadir, M Ohh, DA Foster - Journal of Biological …, 2008 - ASBMB
Constitutive expression of hypoxia-inducible factor (HIF) has been implicated in several
proliferative disorders. Constitutive expression of HIF1α and HIF2α has been linked to a
number of human cancers, especially renal cell carcinoma (RCC), in which HIF2α
expression is the more important contributor. Expression of HIF1α is dependent on the
mammalian target of rapamycin (mTOR) and is sensitive to rapamycin. In contrast, there
have been no reports linking HIF2α expression with mTOR. mTOR exists in two complexes …
proliferative disorders. Constitutive expression of HIF1α and HIF2α has been linked to a
number of human cancers, especially renal cell carcinoma (RCC), in which HIF2α
expression is the more important contributor. Expression of HIF1α is dependent on the
mammalian target of rapamycin (mTOR) and is sensitive to rapamycin. In contrast, there
have been no reports linking HIF2α expression with mTOR. mTOR exists in two complexes …