Non-obese diabetic (NOD) mice exhibit an increased cellular immune response to glycated-LDL but are resistant to high fat diet induced atherosclerosis
P Keren, J George, G Keren, D Harats - Atherosclerosis, 2001 - Elsevier
Diabetes mellitus is one of the major risk factors for atherosclerosis. In recent years several
murine models have been developed in an attempt to reproduce the accelerated
atherosclerosis by combining induced hyperglycemia with hyperlipidemia. In the present
study we wished to examine the effect of spontaneous hyperglycemia and hyperlipidemia
induced by high fat diet on atherosclerosis development and on markers of the immune
system in diabetes prone NOD mice. We tested two high fat dietary regimens (with or without …
murine models have been developed in an attempt to reproduce the accelerated
atherosclerosis by combining induced hyperglycemia with hyperlipidemia. In the present
study we wished to examine the effect of spontaneous hyperglycemia and hyperlipidemia
induced by high fat diet on atherosclerosis development and on markers of the immune
system in diabetes prone NOD mice. We tested two high fat dietary regimens (with or without …