Fast-conducting myelinated high-threshold mechanoreceptors (AHTMR) are largely thought
to transmit acute nociception from the periphery. However, their roles in normal withdrawal
and in nerve injury–induced hyperalgesia are less well accepted. Modulation of this
subpopulation of peripheral neurons would help define their roles in withdrawal behaviors.
The optically active proton pump, ArchT, was placed in an adeno-associated virus-type 8
viral vector with the CAG promoter and was administered by intrathecal injection resulting in …