Iam writing in response to the editorial titled “Pre-venting Cognitive Declines in Usual Aging”
by Espeland and Henderson. 1 Prevention of mild cognitive declines preceding diagnosable
Alzheimer disease (AD) and declines in AD dementia will probably be most effective when
the intervention targets a process closely relevant to the disease pathogenesis. 1 Oxidative
stress changes have been shown to precede the cardinal neuropathologic manifestations of
AD. 2 Therapy for AD focuses mainly on the hypotheses that amyloid and the tubular tau …