[HTML][HTML] The orphan nuclear receptor Rev-erbα regulates circadian expression of plasminogen activator inhibitor type 1
Plasminogen activator inhibitor type 1 (PAI-1) is a major physiologic regulator of the
fibrinolytic system and has recently gained recognition as a modulator of inflammation and
atherosclerosis. PAI-1 exhibits circadian rhythmicity in its expression, peaking in the early
morning, which is associated with increased risk for cardiovascular events. However, the
mechanisms that determine PAI-1 circadian rhythmicity remain poorly understood. We
discovered that the orphan nuclear receptor Reverbα, a core component of the circadian …
fibrinolytic system and has recently gained recognition as a modulator of inflammation and
atherosclerosis. PAI-1 exhibits circadian rhythmicity in its expression, peaking in the early
morning, which is associated with increased risk for cardiovascular events. However, the
mechanisms that determine PAI-1 circadian rhythmicity remain poorly understood. We
discovered that the orphan nuclear receptor Reverbα, a core component of the circadian …