Diagnosis and classification of diabetes mellitus

American Diabetes Association - Diabetes care, 2010 - Am Diabetes Assoc
American Diabetes Association
Diabetes care, 2010Am Diabetes Assoc
MELLITUS—Diabetes is a group of metabolic diseases characterized by hyperglycemia
resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia
of diabetes is associated with long-term damage, dysfunction, and failure of differentorgans,
especially the eyes, kidneys, nerves, heart, and blood vessels. Several pathogenic
processes are involved in the development of diabetes. These range from autoimmune
destruction of the-cells of the pancreas with consequent insulin deficiency to abnormalities …
MELLITUS—Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
Several pathogenic processes are involved in the development of diabetes. These range from autoimmune destruction of the-cells of the pancreas with consequent insulin deficiency to abnormalities that result in resistance to insulin action. The basis of the abnormalities in carbohydrate, fat, and protein metabolism in diabetes is deficient action of insulin on target tissues. Deficient insulin action results from inadequate insulin secretion and/or diminished tissue responses to insulin at one or more points in the complex pathways of hormone action. Impairment of insulin secretion and defects in insulin action frequently coexist in the same patient, and it is often unclear which abnormality, if either alone, is the primary cause of the hyperglycemia. Symptoms of marked hyperglycemia include polyuria, polydipsia, weight loss, sometimes with polyphagia, and blurred vision. Impairment of growth and susceptibility to certain infections may also accompany chronic hyperglycemia. Acute, life-threatening consequences of uncontrolled diabetes are hyperglycemia with ketoacidosis or the nonketotic hyperosmolar syndrome.
Am Diabetes Assoc