[HTML][HTML] Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins: Thematic Review Series: ApoE …

TPV Huynh, AA Davis, JD Ulrich, DM Holtzman - Journal of lipid research, 2017 - ASBMB
Alzheimer's disease (AD) is one of the fastest-growing causes of death and disability in
persons 65 years of age or older, affecting more than 5 million Americans alone. Clinical
manifestations of AD include progressive decline in memory, executive function, language,
and other cognitive domains. Research efforts within the last three decades have identified
APOE as the most significant genetic risk factor for late-onset AD, which accounts for> 99%
of cases. The apoE protein is hypothesized to affect AD pathogenesis through a variety of …