The prognostic value of BRCA1 and PARP expression in epithelial ovarian carcinoma: immunohistochemical detection
M Hjortkjær, M Waldstrøm, A Jakobsen… - International Journal …, 2017 - journals.lww.com
BRCA1/2 mutation status in epithelial ovarian cancer (EOC) presently relies on genetic
testing which is resource consuming. Immunohistochemistry is cheap, fairly reproducible,
and may identify gene product alterations due to both germline and somatic mutations and
other defects along the BRCA gene pathway (BRCAness phenomenon), which is important
when treatment with poly (adenosine-diphosphate-ribose) polymerase (PARP) inhibitors is
considered. The aim of this study was to investigate immunohistochemical detection of …
testing which is resource consuming. Immunohistochemistry is cheap, fairly reproducible,
and may identify gene product alterations due to both germline and somatic mutations and
other defects along the BRCA gene pathway (BRCAness phenomenon), which is important
when treatment with poly (adenosine-diphosphate-ribose) polymerase (PARP) inhibitors is
considered. The aim of this study was to investigate immunohistochemical detection of …