Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome
H Godoy, P Mhawech-Fauceglia, A Beck… - International journal …, 2011 - journals.lww.com
PARP, poly (adenosine diphosphate-ribose) polymerase, is a damage-sensing protein,
which is essential for the repair of DNA single-strand breaks. PARP and p53 function
synergistically in repairing DNA damage and suppressing chromosomal rearrangements.
The aim of this study was to determine the expression of PARP and p53 in epithelial ovarian
cancer (EOC) and to correlate their expression with clinicopathologic characteristics. PARP
and p53 were evaluated using immunohistochemistry applied on a tissue microarray of 189 …
which is essential for the repair of DNA single-strand breaks. PARP and p53 function
synergistically in repairing DNA damage and suppressing chromosomal rearrangements.
The aim of this study was to determine the expression of PARP and p53 in epithelial ovarian
cancer (EOC) and to correlate their expression with clinicopathologic characteristics. PARP
and p53 were evaluated using immunohistochemistry applied on a tissue microarray of 189 …