[HTML][HTML] Human milk hyaluronan enhances innate defense of the intestinal epithelium
DR Hill, HK Rho, SP Kessler, R Amin, CR Homer… - Journal of Biological …, 2013 - ASBMB
Background: Human milk contains hyaluronan (HA). Results: Milk HA concentration is
highest immediately after delivery. Treatment of epithelium with physiologic levels of milk-
derived HA increases intracellular expression of β-defensin (in vitro and in vivo) and
resistance to Salmonella. Conclusion: Milk HA enhances functional antimicrobial defense
mechanisms of the intestinal epithelium. Significance: Milk HA may be a mediator of
maternal protection of newborns. Breast-feeding is associated with enhanced protection …
highest immediately after delivery. Treatment of epithelium with physiologic levels of milk-
derived HA increases intracellular expression of β-defensin (in vitro and in vivo) and
resistance to Salmonella. Conclusion: Milk HA enhances functional antimicrobial defense
mechanisms of the intestinal epithelium. Significance: Milk HA may be a mediator of
maternal protection of newborns. Breast-feeding is associated with enhanced protection …