Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation

S Burgdorf, A Kautz, V Böhnert, PA Knolle, C Kurts - science, 2007 - science.org
S Burgdorf, A Kautz, V Böhnert, PA Knolle, C Kurts
science, 2007science.org
The mechanisms that allow antigen-presenting cells (APCs) to selectively present
extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells
are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to
simultaneously introduce soluble antigen into separate intracellular compartments, which
were dedicated to presentation to CD8+ or CD4+ T cells. Specifically, the mannose receptor
supplied an early endosomal compartment distinct from lysosomes, which was committed to …
The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8+ or CD4+ T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis.
AAAS