Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants
VK Ulaganathan, A Ullrich - Molecular & Cellular Oncology, 2016 - Taylor & Francis
VK Ulaganathan, A Ullrich
Molecular & Cellular Oncology, 2016•Taylor & FrancisIn cancer biology, somatic mutations in the extracellular (ligand binding) and cytosolic
(functional/catalytic) domains are pursued with great interest. However, in our recent
publication we report that germline mutations in the membrane-proximal region of type I
receptors are able to modulate the amplitude of signal transducer and activator of
transcription 3 (STAT3) signaling in cells. This unexpected finding has implications for the
prognosis of heritable cancer.
(functional/catalytic) domains are pursued with great interest. However, in our recent
publication we report that germline mutations in the membrane-proximal region of type I
receptors are able to modulate the amplitude of signal transducer and activator of
transcription 3 (STAT3) signaling in cells. This unexpected finding has implications for the
prognosis of heritable cancer.
Abstract
In cancer biology, somatic mutations in the extracellular (ligand binding) and cytosolic (functional/catalytic) domains are pursued with great interest. However, in our recent publication we report that germline mutations in the membrane-proximal region of type I receptors are able to modulate the amplitude of signal transducer and activator of transcription 3 (STAT3) signaling in cells. This unexpected finding has implications for the prognosis of heritable cancer.
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