Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation
T Niki, S Tsutsui, S Hirose, S Aradono… - Journal of biological …, 2009 - ASBMB
Galectin (Gal)-9 was first described as an eosinophil chemoattractant. With the progress in
research, Gal-9 has come to be known as a versatile immunomodulator that is involved in
various aspects of immune regulations, and the entire picture of the function still remains
elusive. To uncover as-yet unknown activity of Gal-9, we have been examining the effect of
the protein in various disease animal models. Here we show that Gal-9 attenuated asthmatic
reaction in guinea pigs and suppressed passive-cutaneous anaphylaxis in mice. These …
research, Gal-9 has come to be known as a versatile immunomodulator that is involved in
various aspects of immune regulations, and the entire picture of the function still remains
elusive. To uncover as-yet unknown activity of Gal-9, we have been examining the effect of
the protein in various disease animal models. Here we show that Gal-9 attenuated asthmatic
reaction in guinea pigs and suppressed passive-cutaneous anaphylaxis in mice. These …
