Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis
VY Hu, P Zvara, A Dattilio, TL Redman, SJ Allen… - The Journal of …, 2005 - Elsevier
PURPOSE:: Studies suggest that nerve growth factor (NGF) contributes to bladder
overactivity stemming from bladder inflammation. Studies were performed to determine the
NGF dependence of cyclophosphamide (CYP) induced changes in bladder function using
the recombinant NGF sequestering protein REN1820. MATERIALS AND METHODS::
Urodynamic testing and behavioral observations were made in female rats treated with CYP
(4 or 48 hours) and REN1820 or vehicle. RESULTS:: Rats examined 4 or 48 hours after CYP …
overactivity stemming from bladder inflammation. Studies were performed to determine the
NGF dependence of cyclophosphamide (CYP) induced changes in bladder function using
the recombinant NGF sequestering protein REN1820. MATERIALS AND METHODS::
Urodynamic testing and behavioral observations were made in female rats treated with CYP
(4 or 48 hours) and REN1820 or vehicle. RESULTS:: Rats examined 4 or 48 hours after CYP …