[HTML][HTML] Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4 …
β-Arrestins, originally discovered to desensitize activated G protein-coupled receptors,(aka
seven-transmembrane receptors, 7TMRs) also mediate 7TMR internalization and G protein-
independent signaling via these receptors. More recently, several regulatory roles of β-
arrestins for atypical 7TMRs and non-7TM receptors have emerged. Here, we uncover an
entirely novel regulatory role of β-arrestins in cross-talk between the angiotensin receptor
(AT1aR) and a member of the transient receptor potential (TRP) ion channel family, TRPV4 …
seven-transmembrane receptors, 7TMRs) also mediate 7TMR internalization and G protein-
independent signaling via these receptors. More recently, several regulatory roles of β-
arrestins for atypical 7TMRs and non-7TM receptors have emerged. Here, we uncover an
entirely novel regulatory role of β-arrestins in cross-talk between the angiotensin receptor
(AT1aR) and a member of the transient receptor potential (TRP) ion channel family, TRPV4 …