An inducible transgene reports activation of macrophages in live zebrafish larvae

LE Sanderson, AT Chien, JW Astin, KE Crosier… - Developmental & …, 2015 - Elsevier
Macrophages are the most functionally heterogenous cells of the hematopoietic system.
Given many diseases are underpinned by inappropriate macrophage activation,
macrophages have emerged as a therapeutic target to treat disease. A thorough
understanding of what controls macrophage activation will likely reveal new pathways that
can be manipulated for therapeutic benefit. Live imaging fluorescent macrophages within
transgenic zebrafish larvae has provided a valuable window to investigate macrophage …