Junctional Adhesion Molecules (JAMs) have been described as major components of tight
junctions in endothelial and epithelial cells. Tight junctions are crucial for the establishment
and maintenance of cell polarity. During tumor development, they are remodeled, enabling
neoplastic cells to escape from constraints imposed by intercellular junctions and to adopt a
migratory behavior. Using a carcinoma cell line we tested whether JAM-C could affect tight
junctions and migratory properties of tumor cells. We show that transfection of JAM-C …