Combined evidence from three large British Association studies rejects TUCAN/CARD8 as an IBD susceptibility gene
SA Fisher, MM Mirza, CM Onnie, D Soars… - …, 2007 - gastrojournal.org
Dear Sir: The importance of CARD15 mutations in susceptibility to Crohn's disease (CD) 1–3
and its role in the activation of nuclear factor-κB provides a compelling case for the
involvement of other genes in this signaling pathway. We therefore read with interest the
recent report by McGovern et al 4 of a novel association between a variant in the CARD8
gene and inflammatory bowel disease (IBD). The CARD8 protein, also known as TUCAN
(tumour–up-regulated CARD-containing antagonist of caspase nine) is a 48-kDa peptide …
and its role in the activation of nuclear factor-κB provides a compelling case for the
involvement of other genes in this signaling pathway. We therefore read with interest the
recent report by McGovern et al 4 of a novel association between a variant in the CARD8
gene and inflammatory bowel disease (IBD). The CARD8 protein, also known as TUCAN
(tumour–up-regulated CARD-containing antagonist of caspase nine) is a 48-kDa peptide …